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Article

The natural history of Noonan syndrome: a long-term follow-up study.

Archives of disease in childhood - 1 Feb 2007

Shaw A C, Kalidas K, Crosby A H, Jeffery S, Patton M A

Abstract excerpt

OBJECTIVE: To define better the adult phenotype and natural history of Noonan syndrome. DESIGN: A prospective observational study of a large cohort. RESULTS: Data are presented for 112 individuals with Noonan syndrome (mean age 25.3 (range 12-71) years), who were followed up for a mean of 12.02 years. Mutations in PTPN11 were identified in 35% of probands. Ten subjects died during the study interval; three of...

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Identifiers

PMID: 16990350
DOI: 10.1136/adc.2006.104547
PMCID: PMC2083343

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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