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Article

Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent

1 Sept 2006

Abstract excerpt

Despite advances in surgery, radiation, and chemotherapy, novel therapeutics are needed for head and neck cancer treatment. The objective of this current study was to evaluate alexidine dihydrochloride as a novel compound lead for head and neck cancers. Using a tetrazolium-based assay, the dose required to reduce cell viability by 50% (ED50) was found to be approximately 1.8 micromol/L in FaDu (human...

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PMID: 16985057
DOI: 10.1158/1535-7163.mct-06-0134

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