Article
Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.
Blood - 1 Jan 2007
Delhommeau François, Dupont Sabrina, Tonetti Carole, Massé Aline, Godin Isabelle, Le Couedic Jean-Pierre, Debili Najet, Saulnier Patrick, Casadevall Nicole, Vainchenker William, Giraudier Stéphane
Abstract excerpt
The JAK2 V617F mutation has recently been described as an essential oncogenic event associated with polycythemia vera (PV), idiopathic myelofibrosis (IMF), and essential thrombocythemia. This mutation has been detected in all myeloid lineages but has not yet been detected in lymphoid cells. This raises the question whether this molecular event occurs in a true lymphomyeloid progenitor cell. In this work, we...
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