Article
Biochemical basis of prolidase deficiency. Polypeptide and RNA phenotypes and the relation to clinical phenotypes.
The Journal of clinical investigation - 1 Jan 1990
Endo F, Tanoue A, Kitano A, Arata J, Danks D M, Lapière C M, Sei Y, Wadman S K, Matsuda I
Abstract excerpt
Cultured skin fibroblasts or lymphoblastoid cells from eight patients with clinical symptoms of prolidase deficiency were analyzed in terms of enzyme activity, presence of material crossreacting with specific antibodies, biosynthesis of the polypeptide, and mRNA corresponding to the enzyme. There...
Topics
- Adolescent
- Adult
- Amino Acid Metabolism, Inborn Errors
- Blotting, Northern
- Cells, Cultured
- Child
- Dipeptidases
- Erythrocytes
- Female
- Fibroblasts
- Humans
- Kinetics
- Lymphocytes
- Macromolecular Substances
- Male
- Methionine
- Phenotype
- RNA