Most difficult asthma originates primarily in adult life.

Abstract excerpt

Epidemiological studies indicate that most asthma starts in childhood. However, the characteristics of adults with difficult asthma differ from the general asthma population. Difficult asthma as defined by poor control despite high dose inhaled steroids and long acting beta 2 agonists disproportionately affects women, more often has onset in adult life and is less frequently associated with atopy, and therefore...

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