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Article

Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2006

Azam Mohammad, Nardi Valentina, Shakespeare William C, Metcalf Chester A, Bohacek Regine S, Wang Yihan, Sundaramoorthi Raji, Sliz Piotr, Veach Darren R, Bornmann William G, Clarkson Bayard, Dalgarno David C, Sawyer Tomi K, Daley George Q

Abstract excerpt

Mutation in the ABL kinase domain is the principal mechanism of imatinib resistance in patients with chronic myelogenous leukemia. Many mutations favor active kinase conformations that preclude imatinib binding. Because the active forms of ABL and SRC resemble one another, we tested two dual SRC-...

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Identifiers

PMID: 16754879
DOI: 10.1073/pnas.0600001103
PMCID: PMC1482597

Genes

SRC
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16754879-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.PMID 16754879Read ↗

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