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Article

Malignant hyperthermia in Japan: mutation screening of the entire ryanodine receptor type 1 gene coding region by direct sequencing.

Anesthesiology - 1 Jun 2006

Ibarra M Carlos A, Wu Shiwen, Murayama Kumiko, Minami Narihiro, Ichihara Yasuko, Kikuchi Hirosato, Noguchi Satoru, Hayashi Yukiko K, Ochiai Ryoichi, Nishino Ichizo

Abstract excerpt

BACKGROUND: Malignant hyperthermia (MH) is a disorder of calcium homeostasis in skeletal muscle triggered by volatile anesthetics or succinylcholine in susceptible persons. More than 100 mutations in the ryanodine receptor type 1 gene (RYR1) have been associated with MH susceptibility, central core disease, or both. RYR1 mutations may account for up to 70% of MH-susceptible cases. The authors aimed to determine...

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Identifiers

PMID: 16732084
DOI: 10.1097/00000542-200606000-00008

Genes

RYR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Malignant hyperthermia in Japan: mutation screening of the entire ryanodine receptor type 1 gene coding region by direct sequencing.PMID 16732084Read ↗

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