Plasmodium falciparum: genetic stability of the Uganda Palo Alto strain propagated in the squirrel monkey (Saimiri sciureus).

Abstract excerpt

The Uganda Palo Alto strain of Plasmodium falciparum has been extensively used in several laboratories to infect Saimiri monkeys. In the study reported here three distinct lines derived by parallel serial blood transfers from a single 10-year-old passage of the Palo Alto strain were examined for genetic diversity using the polymerase chain reaction and restriction mapping techniques. A comparison of the PF 11.1,...

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