Loss of capsule expression by Haemophilus influenzae type b results in enhanced adherence to and invasion of human cells.

doi:10.1128/iai.59.4.1325-1333.1991

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Article

Loss of capsule expression by Haemophilus influenzae type b results in enhanced adherence to and invasion of human cells.

Infection and immunity - 1 Apr 1991

St Geme J W, Falkow S

Abstract excerpt

Haemophilus influenzae type b is a common cause of systemic bacterial disease in children, and the serotype b capsule is a major determinant of virulence. Nevertheless, as a consequence of the genetic configuration of the capb locus, type b strains become capsule deficient at a high frequency. To...

Topics

Bacterial Adhesion
Cells, Cultured
Fimbriae, Bacterial
Haemophilus influenzae
Humans
Microscopy, Electron
Mutation
Transformation, Bacterial

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