Article
Loss of capsule expression by Haemophilus influenzae type b results in enhanced adherence to and invasion of human cells.
Infection and immunity - 1 Apr 1991
St Geme J W, Falkow S
Abstract excerpt
Haemophilus influenzae type b is a common cause of systemic bacterial disease in children, and the serotype b capsule is a major determinant of virulence. Nevertheless, as a consequence of the genetic configuration of the capb locus, type b strains become capsule deficient at a high frequency. To investigate the potential biological relevance of the predisposition to capsule loss, we compared the adherent and...
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