Article
Diffuse micronodular pulmonary metastasis of lung adenocarcinoma predicts gefitinib response in association with epidermal growth factor receptor mutations.
Anticancer research - 1 Jan 2000
Kobayashi Makoto, Takeuchi Tamotsu, Bandobashi Kentaro, Uemura Yoshiki, Ogawa Yasuhiro, Ohtsuki Yuji, Taguchi Hirokuni
Abstract excerpt
Female, non-smoker, Asian ethnicity and adenocarcinoma histology are the major clinical predictors of gefitinib response in non-small cell lung cancer, as shown in previous studies. Recently, response to gefitinib has been associated with epidermal growth factor receptor (EGFR) mutations. Higher rates of mutation were seen in females, patients with adenocarcinomas, the Asian population and never-smokers, which...
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