Article
Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6): support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes.
BMC medical genetics - 28 Mar 2006
Matolweni Luzuko O, Bardien Soraya, Rebello George, Oppon Ekow, Munclinger Miroslav, Ramesar Rajkumar, Watkins Hugh, Mayosi Bongani M
Abstract excerpt
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable disorder characterized by progressive degeneration of right ventricular myocardium, arrhythmias and an increased risk of sudden death at a young age. By linkage analysis, ARVC type 6 was previously mapped to a 10.6 cM region on chromosome 10p12-p14 in a large North American kindred. To date, the genetic defect that causes ARVC6 has...
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