Article
No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Mar 2006
Shah Paresh R, Ahmad-Annuar Azlina, Ahmadi Kourosh R, Russ Carsten, Sapp Peter C, Horvitz H Robert, Brown Robert H, Goldstein David B, Fisher Elizabeth M C
Abstract excerpt
The cytoplasmic dynein-dynactin complex has been implicated in the aetiology of motor neuron degeneration in both mouse models and human forms of motor neuron disease. We have previously shown that mutations in the cytoplasmic dynein 1 heavy chain 1 gene (Dync1h1) are causal in a mouse model of late-onset motor neuron degeneration but have found no association of the homologous sites in human DYNC1H1 with human...
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