Article
Molecular basis of globoid cell leukodystrophy in Irish setters.
Veterinary journal (London, England : 1997) - 1 Mar 2006
McGraw Royal A, Carmichael K Paige
Abstract excerpt
Globoid cell leukodystrophy (GLD), or Krabbe's disease, is a progressive autosomal recessive disorder of the central nervous system in man and in various other species. GLD has been shown to result from various mutations in the gene encoding galactocerebrosidase (GALC), a lysosomal enzyme. We investigated the molecular basis of GLD in a related group of Irish setters. Sequencing of the GALC cDNA from an affected...
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