Article
Expansion of the SOX gene family predated the emergence of the Bilateria.
Molecular phylogenetics and evolution - 1 May 2006
Jager Muriel, Quéinnec Eric, Houliston Evelyn, Manuel Michaël
Abstract excerpt
Members of the SOX gene family are involved in regulating many developmental processes including neuronal determination and differentiation, and in carcinogenesis. So far they have only been identified in species from the Bilateria (deuterostomes and protostomes). To understand the origins of the SOX family, we used a PCR-based strategy to obtain 28 new sequences of SOX gene HMG domains from four non-bilaterian...
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