Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modifier genes and oligogenic disease.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi - 1 Dec 2005

Agarwal Sarita, Moorchung Nikhil

Abstract excerpt

It is now increasingly apparent that modifier genes have a considerable role to play in phenotypic variations of single-gene disorders. Intrafamilial variations, altered penetrance, and altered severity are now common features of single gene disorders because of the involvement of several genes in the expression of the disease phenotype. Oligogenic disorders occur because of a second gene modifying the action of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Diseases, Inborn
Share to Genetic Variation
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multifactorial Inheritance

Share to Phenotype

Source

Identifiers

PMID: 16415512
DOI: 10.1272/jnms.72.326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Modifier genes and oligogenic disease.PMID 16415512Read ↗

Genetic modifiers and oligogenic inheritance.Semantic proximity Read ↗

Modifier genes in humans: strategies for identification.Semantic proximity Read ↗

Identifying modifier genes of monogenic disease: strategies and difficulties.Semantic proximity Read ↗

Modifier genes convert "simple" Mendelian disorders to complex traits.Semantic proximity Read ↗

Modifier genes in mice and humans.Semantic proximity Read ↗

Modifier genes and protective alleles in humans and mice.Semantic proximity Read ↗

Disease-modifying genes and monogenic disorders: experience in cystic fibrosisSemantic proximity Read ↗

Genetic modifiers in human development and malformation syndromes, including chaperone proteins.Semantic proximity Read ↗

Multiple Structural Microform Defects Suggest Role of Modifier Genes.Semantic proximity Read ↗

Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes.Semantic proximity Read ↗

Modifier genes and variation in cystic fibrosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.