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Article

Double trisomy in spontaneous miscarriages: cytogenetic and molecular approach

16 Dec 2005

Abstract excerpt

BACKGROUND: Although single trisomy is the most common chromosomal abnormality observed within first trimester spontaneous abortions (SA) (>50%), double trisomy (DT) ranges from 0.21 to 2.8% in the literature. Since little is known about mechanisms underlying DT, we report the results of our experience with 517 SA, establishing parental origin and cell stage of non-disjunction when possible in DT cases, and...

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PMID: 16361293
DOI: 10.1093/humrep/dei406

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