Article
Identification of the central quorum sensing regulator of virulence in the enteric phytopathogen, Erwinia carotovora: the VirR repressor.
Molecular microbiology - 1 Jan 2006
Burr Tom, Barnard Anne M L, Corbett Mark J, Pemberton Clare L, Simpson Natalie J L, Salmond George P C
Abstract excerpt
In the Gram-negative phytopathogen, Erwinia carotovora ssp. atroseptica (Eca) virulence depends on the production of a N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) quorum sensing (QS) signal. This work identifies the elusive 'missing link' between QS and virulence in Erwinia. We have identified and characterized a novel regulator of virulence, VirR, in Eca and show that a virR mutation completely restores...
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