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Article

Gln49 and Ser174 residues play critical roles in determining the catalytic efficiencies of plant glutamine synthetase.

Plant & cell physiology - 1 Feb 2006

Ishiyama Keiki, Inoue Eri, Yamaya Tomoyuki, Takahashi Hideki

Abstract excerpt

Two essential residues playing critical roles in determining the substrate specificities of cytosolic glutamine synthetase (GS1) have been identified from the alignment of high-affinity (GLN1;1 and GLN1;4) and low-affinity (GLN1;2 and GLN1;3) GS1 isoenzymes in Arabidopsis, and confirmed by site-directed mutagenesis. The results indicated that either K49Q or A174S mutation is sufficient to increase the catalytic...

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PMID: 16338958
DOI: 10.1093/pcp/pci238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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