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Article

The heat-sensitive Escherichia coli grpE280 phenotype: impaired interaction of GrpE(G122D) with DnaK.

Journal of molecular biology - 4 Nov 2005

Grimshaw John P A, Siegenthaler Rahel K, Züger Sara, Schönfeld Hans-Joachim, Z'graggen Birgit Roth, Christen Philipp

Abstract excerpt

GrpE is the nucleotide-exchange factor of the DnaK chaperone system. Escherichia coli cells with the classical temperature-sensitive grpE280 phenotype do not grow under heat-shock conditions and have been found to carry the G122D point mutation in GrpE. To date, the molecular mechanism of this defect has not been investigated in detail. Here, we examined the structural and functional properties of isolated...

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Identifiers

PMID: 16198374
DOI: 10.1016/j.jmb.2005.08.069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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