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Article

AEC-associated p63 mutations lead to alternative splicing/protein stabilization of p63 and modulation of Notch signaling.

Cell cycle (Georgetown, Tex.) - 1 Oct 2005

Huang Yi-Ping, Kim Yuriy, Li Zhaobo, Fomenkov Tanya, Fomenkov Alexey, Ratovitski Edward A

Abstract excerpt

p63, the major regulator of epithelial development/differentiation, is mutated in human ectodermal dysplasias, such as ankyloblepharon, ectodermal dysplasia and clefting (AEC). We recently identified that p63alpha physically associated with mRNA processing/splicing proteins. We previously showed that p63 mutations mapped to the sterile alpha-motif led to disruption of these interactions and modulated an aberrant...

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Identifiers

PMID: 16177572
DOI: 10.4161/cc.4.10.2086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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