Article
Frequency of bovine Nramp1 (Slc11a1) alleles in Holstein and Zebu breeds.
Veterinary immunology and immunopathology - 15 Jan 2006
Paixão Tatiane A, Ferreira Cintia, Borges Alan M, Oliveira Denise A A, Lage Andrey P, Santos Renato L
Abstract excerpt
Natural resistance against brucellosis in cattle is linked to the Nramp1 gene, which encodes a divalent cation transporter that localizes in the phagolysosome membrane in macrophages. Nramp1 gene in mouse plays a critical role in innate immunity favoring bacterial killing by macrophages in addition to its influence on adaptative immunity. Polymorphisms at the bovine Nramp1 3' untranslated region (3'UTR),...
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