Article
Peginterferon alfa-2b and ribavirin for 12 vs. 24 weeks in HCV genotype 2 or 3.
The New England journal of medicine - 23 Jun 2005
Mangia Alessandra, Santoro Rosanna, Minerva Nicola, Ricci Giovanni L, Carretta Vito, Persico Marcello, Vinelli Francesco, Scotto Gaetano, Bacca Donato, Annese Mauro, Romano Mario, Zechini Franco, Sogari Fernando, Spirito Fulvio, Andriulli Angelo
Abstract excerpt
BACKGROUND: We hypothesized that in patients with hepatitis C virus (HCV) genotype 2 or 3 in whom HCV RNA is not detectable after 4 weeks of therapy, 12 weeks of treatment is as effective as 24 weeks. METHODS: A total of 283 patients were randomly assigned to a standard 24-week regimen of peginterferon alfa-2b at a dose of 1.0 mug per kilogram weekly plus ribavirin at a dose of 1000 mg or 1200 mg daily, on the...
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