Article
[Genetic hypophosphatemia: recent advances in physiopathogenic concept].
Annales d'endocrinologie - 1 Apr 2005
Beraud G, Perimenis P, Velayoudom Fr-L, Wemeau J-L, Vantyghem M-Chr
Abstract excerpt
Renal proximal tubular reabsorption of phosphate and intestinal absorption both regulate phosphate homeostasis. Brush-border membrane Npt2a cotransporter is the key element in proximal tubular P (i) reabsorption. Inactivating mutations of Npt2a cause bone demineralisation and urolithiasis. An excess of a phosphaturic factor, called "Phosphatonin", could modulate phosphate reabsorption by inhibition on Npt2a....
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