Limb-girdle muscular dystrophies: heterogeneity of clinical phenotypes and pathogenetic mechanisms.

Abstract excerpt

Limb-girdle muscular dystrophies, inherited muscle disorders characterized by progressive weakness and muscle wasting, can be classified into different types, according to their genetic inheritance, distribution of weakness, and molecular defect. The most common clinical forms are autosomal recessive and with proximal involvement, and are classified as limb-girdle muscular dystrophies 2A-2J, with clinical...

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