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Article

Aspartoacylase gene knockout in the mouse: impact on reproduction.

Reproductive toxicology (Elmsford, N.Y.) - 1 Jan 2000

Surendran Sankar, Szucs Sylvia, Tyring Stephen K, Matalon Reuben

Abstract excerpt

Canavan disease (CD) is an autosomal recessive disorder caused by aspartoacylase (ASPA) gene mutations resulting enzyme deficiency. The homozygous knockout mouse for CD showed symptoms similar observed in patients with CD. Canavan disease leads to early death. Therefore, a role of ASPA in reproduction was investigated using the mouse model for CD. Homozygous (KO/KO) pups, produced by mating female heterozygous...

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Source

Identifiers

PMID: 15907664
DOI: 10.1016/j.reprotox.2005.02.001

Genes

ASPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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