Article
Mutational analysis of the MRP2 gene and long-term follow-up of Dubin-Johnson syndrome in Japan.
Journal of gastroenterology - 1 Apr 2005
Machida Ikuo, Wakusawa Shinya, Sanae Fujiko, Hayashi Hisao, Kusakabe Atsushi, Ninomiya Hiroshi, Yano Motoyoshi, Yoshioka Kentaro
Abstract excerpt
BACKGROUND: Recent studies have indicated that dysfunction or loss of the multidrug resistance protein 2 (MRP2) is the molecular basis of Dubin-Johnson syndrome (DJS). To clarify the genetic basis of the disease and the long-term stability of serum bilirubin levels, we conducted a mutational anal...
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