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Article

Mutational analysis of the MRP2 gene and long-term follow-up of Dubin-Johnson syndrome in Japan.

Journal of gastroenterology - 1 Apr 2005

Machida Ikuo, Wakusawa Shinya, Sanae Fujiko, Hayashi Hisao, Kusakabe Atsushi, Ninomiya Hiroshi, Yano Motoyoshi, Yoshioka Kentaro

Abstract excerpt

BACKGROUND: Recent studies have indicated that dysfunction or loss of the multidrug resistance protein 2 (MRP2) is the molecular basis of Dubin-Johnson syndrome (DJS). To clarify the genetic basis of the disease and the long-term stability of serum bilirubin levels, we conducted a mutational analysis of the MRP2 gene and followed up serum bilirubin levels in Japanese DJS patients 30 years after they were...

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PMID: 15870973
DOI: 10.1007/s00535-004-1555-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutational analysis of the MRP2 gene and long-term follow-up of Dubin-Johnson syndrome in Japan.PMID 15870973Read ↗

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