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Article

Hb H disease in a Turkish family resulting from the interaction of a deletional alpha-thalassaemia-1 and a newly discovered poly A mutation.

British journal of haematology - 1 Apr 1992

Yüregir G T, Aksoy K, Cürük M A, Dikmen N, Fei Y J, Baysal E, Huisman T H

Abstract excerpt

We have analysed the alpha-globin gene defects present in several members of a large family from Southern Turkey. One deletional alpha-thalassaemia-1 (type MED-II) was found in 10 subjects: this deletion is in excess of 26.5 kb and includes all zeta- and alpha-globin genes. Besides the common types of deletional alpha-thalassaemia-2 (-3.7 kb and -4.2 kb) we observed a nondeletional alpha-thalassaemia-2 that...

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PMID: 1581238
DOI: 10.1111/j.1365-2141.1992.tb04568.x

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