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Article

Homozygous and Heterozygous Expression of a Novel Insulin-Like Growth Factor-I Mutation

1 May 2005

Abstract excerpt

IGF-I is a key factor in intrauterine development and postnatal growth and metabolism. The secretion of IGF-I in utero is not dependent on GH, whereas in childhood and adult life, IGF-I secretion seems to be mainly controlled by GH, as revealed from studies on patients with GHRH receptor and GH receptor mutations. In a 55-yr-old male, the first child of consanguineous parents, presenting with severe intrauterine...

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PMID: 15769976
DOI: 10.1210/jc.2004-1254

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