Functional promotor polymorphism in RANTES gene does not influence the clinical course of Helicobacter pylori infection.

Abstract excerpt

BACKGROUND AND AIMS: Helicobacter pylori was found to increase the transcription of RANTES as a potent chemoattractant cytokine in mucosal inflammation. The aim of this study was to test if a functional promotor polymorphism in the RANTES gene leading to a higher transcriptional activity influences the severity of the mucosal damage in H. pylori infected individuals. METHODS: A single nucleotide polymorphism,...

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