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Article

Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response.

Molecular and cellular biology - 1 Feb 2005

Shen Jingshi, Snapp Erik L, Lippincott-Schwartz Jennifer, Prywes Ron

Abstract excerpt

Endoplasmic reticulum (ER) stress-induced activation of ATF6, an ER membrane-bound transcription factor, requires a dissociation step from its inhibitory regulator, BiP. It has been generally postulated that dissociation of the BiP-ATF6 complex is a result of the competitive binding of misfolded proteins generated during ER stress. Here we present evidence against this model and for an active regulatory mechanism...

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Source

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Identifiers

PMID: 15657421
DOI: 10.1128/MCB.25.3.921-932.2005
PMCID: PMC543992

Genes

ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response.PMID 15657421Read ↗

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Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress.Semantic proximity Read ↗

In vivo analysis of the lumenal binding protein (BiP) reveals multiple functions of its ATPase domain.Semantic proximity Read ↗

Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum.Semantic proximity Read ↗

Experimental approaches for elucidation of stress-sensing mechanisms of the IRE1 family proteins.Semantic proximity Read ↗

A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum StressSemantic proximity Read ↗

A Molecular Mechanism for Turning off IRE1α Signaling During Endoplasmic Reticulum StressSemantic proximity Read ↗

ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates.Semantic proximity Read ↗

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ERdj3 regulates BiP occupancy in living cells.Semantic proximity Read ↗

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