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Article

A mutation in the CLN8 gene in English Setter dogs with neuronal ceroid-lipofuscinosis.

Biochemical and biophysical research communications - 11 Feb 2005

Katz Martin L, Khan Shahnawaz, Awano Tomoyuki, Shahid S Adam, Siakotos Aristotle N, Johnson Gary S

Abstract excerpt

A heritable neurodegenerative disease of English Setters has long been studied as a model of human neuronal ceroid-lipofuscinosis (NCL). Megablast searches of the first build of the canine genome for potential causative genes located the CLN8 gene near the q telomere of canine chromosome 37, close to a marker previously linked to English Setter NCL. Sequence analysis of the coding region from affected dogs...

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Source

Identifiers

PMID: 15629147
DOI: 10.1016/j.bbrc.2004.12.038

Genes

CLN8
NCL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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