Article
Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus.
The Journal of clinical investigation - 1 Dec 2004
Melles Damian C, Gorkink Raymond F J, Boelens Hélène A M, Snijders Susan V, Peeters Justine K, Moorhouse Michael J, van der Spek Peter J, van Leeuwen Willem B, Simons Guus, Verbrugh Henri A, van Belkum Alex
Abstract excerpt
The population structure of Staphylococcus aureus carried by healthy humans was determined using a large strain collection of nonclinical origin (n = 829). High-throughput amplified fragment length polymorphism (AFLP) analysis revealed 3 major and 2 minor genetic clusters of S. aureus, which were corroborated by multilocus sequence typing. Major AFLP cluster I comprised 44.4% of the carriage isolates and showed...
Topics
- Cloning, Molecular
- Cluster Analysis
- DNA
- Genetic Techniques
- Genetic Variation
- Genetic Vectors
- Genome, Bacterial
- Genotype
- Humans
- Methicillin
- Models, Genetic
- Multigene Family
- Polymorphism, Genetic