Article
Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport.
Traffic (Copenhagen, Denmark) - 1 Dec 2004
Zhang Shaochong, Ren Jihui, Li Hongzhe, Zhang Qian, Armstrong Jeffery S, Munn Alan L, Yang Hongyuan
Abstract excerpt
The Niemann Pick C1 protein localizes to late endosomes and plays a key role in the intracellular transport of cholesterol in mammalian cells. Cholesterol and other lipids accumulate in a lysosomal or late endosomal compartment in cells lacking normal NPC1 function. Other than accumulation of lipids, defects in lysosomal retroendocytosis, sorting of a multifunctional receptor and endosomal movement have also been...
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