Evolutionary origin of mutations in the primate cytochrome P450c21 gene.

Article

Evolutionary origin of mutations in the primate cytochrome P450c21 gene.

American journal of human genetics - 1 Apr 1992

Kawaguchi H, O'hUigin C, Klein J

Abstract excerpt

The CYP21 gene codes for the enzyme cytochrome P450c21 (21-hydroxylase), which is critically involved in the synthesis of glucocorticoids and mineralocorticoids. Standard human haplotypes contain two copies of CYP21--a functional gene and a pseudogene. Inactivation of the functional gene leads to...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Cell Line
Gorilla gorilla
Molecular Sequence Data
Mutation
Pan troglodytes
Pongo pygmaeus
Restriction Mapping
Steroid 21-Hydroxylase

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