Article
Neural basis of genetically determined visuospatial construction deficit in Williams syndrome.
Neuron - 2 Sept 2004
Meyer-Lindenberg Andreas, Kohn Philip, Mervis Carolyn B, Kippenhan J Shane, Olsen Rosanna K, Morris Colleen A, Berman Karen Faith
Abstract excerpt
A unique opportunity to understand genetic determinants of cognition is offered by Williams syndrome (WS), a well-characterized hemideletion on chromosome 7q11.23 that causes extreme, specific weakness in visuospatial construction (the ability to visualize an object as a set of parts or construct a replica). Using multimodal neuroimaging, we identified a neural mechanism underlying the WS visuoconstructive...
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