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Comparative and genetic analysis of the porcine glucocerebrosidase (GBA) gene.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology - 1 Aug 2004

Stratil Antonín, Wagenknecht Daniel, Van Poucke Mario, Kubícková Svatava, Bartenschlager Heinz, Musilová Petra, Rubes Jirí, Geldermann Hermann, Peelman Luc J

Abstract excerpt

The genomic sequence of the porcine (Sus scrofa) glucocerebrosidase (GBA) gene (approximately 5.7 kb), encoding glucocerebrosidase (glucosylceramidase; acid beta-glucosidase; EC 3.2.1.45), was determined and compared with human (Homo sapiens) GBA and GBAP (pseudogene). The porcine gene harbours 11 exons and 10 introns, and the genomic organization is identical with human GBA. The exon sequences, coding for signal...

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PMID: 15325338
DOI: 10.1016/j.cbpc.2004.04.021

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