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Article

Mutations in the slow skeletal muscle fiber myosin heavy chain gene (MYH7) cause laing early-onset distal myopathy (MPD1).

American journal of human genetics - 1 Oct 2004

Meredith Christopher, Herrmann Ralf, Parry Cheryl, Liyanage Khema, Dye Danielle E, Durling Hayley J, Duff Rachael M, Beckman Kaye, de Visser Marianne, van der Graaff Maaike M, Hedera Peter, Fink John K, Petty Elizabeth M, Lamont Phillipa, Fabian Vicki, Bridges Leslie, Voit Thomas, Mastaglia Frank L, Laing Nigel G

Abstract excerpt

We previously linked Laing-type early-onset autosomal dominant distal myopathy (MPD1) to a 22-cM region of chromosome 14. One candidate gene in the region, MYH7, which is mutated in cardiomyopathy and myosin storage myopathy, codes for the myosin heavy chain of type I skeletal muscle fibers and c...

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Share to Chromosomes, Human, Pair 14
Share to Distal Myopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Haplotypes

Share to Muscle Fibers, Slow-Twitch

Share to Muscle, Skeletal

Share to Myosin Heavy Chains

Share to Sequence Analysis, DNA

Source

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Identifiers

PMID: 15322983
DOI: 10.1086/424760
PMCID: PMC1182058

Genes

MYH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15322983-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Mutations in the slow skeletal muscle fiber myosin heavy chain gene (MYH7) cause laing early-onset distal myopathy (MPD1).PMID 15322983Read ↗

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