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Article

Psychological impact of genetic testing for familial hypercholesterolemia within a previously aware population: a randomized controlled trial.

American journal of medical genetics. Part A - 30 Jul 2004

Marteau Theresa, Senior Victoria, Humphries Steve E, Bobrow Martin, Cranston Treena, Crook Martin A, Day Lorna, Fernandez Maryam, Horne Rob, Iversen Andrew, Jackson Zoe, Lynas Jacqui, Middleton-Price Helen, Savine Richard, Sikorski Jim, Watson Melanie, Weinman John, Wierzbicki Anthony S, Wray Richard

Abstract excerpt

This trial tests the hypothesis that confirming a clinical diagnosis of familial hypercholesterolemia (FH) by finding a genetic mutation reduces patients' perceptions of control over the disease and adherence to risk-reducing behaviors. Three hundred forty-one families, comprising 341 hypercholesterolemia probands and 128 adult relatives, were randomized to one of two groups: (a) routine clinical diagnosis; (b)...

Read the complete abstract on PubMed

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Identifiers

PMID: 15216550
DOI: 10.1002/ajmg.a.30102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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