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Article

Perinuclear biogenesis of mutant torsin-A inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors.

Neuroscience - 1 Jan 2004

Bragg D C, Camp S M, Kaufman C A, Wilbur J D, Boston H, Schuback D E, Hanson P I, Sena-Esteves M, Breakefield X O

Abstract excerpt

TorsinA is a novel protein identified in the search for mutations underlying the human neurologic movement disorder, early onset torsion dystonia. Relatively little is understood about the normal function of torsinA or the physiological effects of the codon deletion associated with most cases of...

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Identifiers

PMID: 15099679
DOI: 10.1016/j.neuroscience.2004.01.053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15099679-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Perinuclear biogenesis of mutant torsin-A inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors.PMID 15099679Read ↗

Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells.Semantic proximity Read ↗

Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.Semantic proximity Read ↗

Aberrant cellular behavior of mutant torsinA implicates nuclear envelope dysfunction in DYT1 dystonia.Semantic proximity Read ↗

Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics.Semantic proximity Read ↗

Inhibition of N-linked glycosylation prevents inclusion formation by the dystonia-related mutant form of torsinA.Semantic proximity Read ↗

Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope.Semantic proximity Read ↗

Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation.Semantic proximity Read ↗

Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant Delta E-torsinA.Semantic proximity Read ↗

TorsinA and dystonia: from nuclear envelope to synapseSemantic proximity Read ↗

Disease Modeling with Human Neurons Reveals LMNB1 Dysregulation Underlying DYT1 DystoniaSemantic proximity Read ↗

LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation.Semantic proximity Read ↗

Disease modeling with human neurons reveals LMNB1 dysregulation underlying DYT1 dystoniaSemantic proximity Read ↗

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