Article
Relationship of estrogen receptor genotypes to bone mineral density and to rates of bone loss in men.
The Journal of clinical endocrinology and metabolism - 1 Apr 2004
Khosla Sundeep, Riggs B Lawrence, Atkinson Elizabeth J, Oberg Ann L, Mavilia Carmelo, Del Monte Francesca, Melton L Joseph, Brandi Maria Luisa
Abstract excerpt
Estrogen is now known to play an important role in bone metabolism in men. Thus, we examined possible relationships between polymorphisms of the estrogen receptor (ER)-alpha and -beta genes, bone mineral density (BMD), and rates of bone loss in an age-stratified random sample of 283 Rochester, Minnesota, men aged 22-90 yr. DNA was analyzed for the XbaI and PvuII ER-alpha and AluI ER-beta polymorphisms. The X/P...
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