Article
Molecular analysis of metallo-beta-lactamase gene bla(SPM-1)-surrounding sequences from disseminated Pseudomonas aeruginosa isolates in Recife, Brazil.
Antimicrobial agents and chemotherapy - 1 Apr 2004
Poirel Laurent, Magalhaes Marcelo, Lopes Miguel, Nordmann Patrice
Abstract excerpt
The spread of clonally related carbapenem-resistant Pseudomonas aeruginosa producing the metallo-beta-lactamase SPM-1 was found in Recife, Brazil. Upstream of bla(SPM-1), a novel common region (CR4) was identified, comprising an open reading frame, orf495, whose product shares significant identity with putative recombinases, such as Orf513. CR4 may be responsible for mobilization and expression of bla(SPM-1).
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.