A maximum principle for the mutation-selection equilibrium of nucleotide sequences.

Abstract excerpt

We study the equilibrium behaviour of a deterministic four-state mutation-selection model as a model for the evolution of a population of nucleotide sequences in sequence space. The mutation model is the Kimura 3ST mutation scheme, and the selection scheme is assumed to be invariant under permutation of sites. Considering the evolution process both forward and backward in time, we use the ancestral distribution...

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