Article
Oral contraception does not alter single dose saquinavir pharmacokinetics in women.
British journal of clinical pharmacology - 1 Mar 2004
Fröhlich Margit, Burhenne Jürgen, Martin-Facklam Meret, Weiss Johanna, von Wolff Michael, Strowitzki Thomas, Walter-Sack Ingeborg, Haefeli Walter E
Abstract excerpt
AIMS: Women experience more adverse drug reactions (ADR) to antiretroviral therapy than men. This may be attributed to higher plasma concentrations of protease inhibitors due to pharmacokinetic interactions with hormonal preparations. Thus, in the present study we aimed to investigate the influence of oral contraceptives (OC) on the pharmacokinetics of the protease inhibitor saquinavir. METHODS: Saquinavir was...
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