Article
Genetic mapping of GBE1 and its association with glycogen storage disease IV in American Quarter horses.
Cytogenetic and genome research - 1 Jan 2003
Ward T L, Valberg S J, Lear T L, Guérin G, Milenkovic D, Swinburne J E, Binns M M, Raudsepp T, Skow L, Chowdhary B P, Mickelson J R
Abstract excerpt
Comparative biochemical and histopathological data suggest that a deficiency in the glycogen branching enzyme (GBE) is responsible for a fatal neonatal disease in Quarter Horse foals that closely resembles human glycogen storage disease type IV (GSD IV). Identification of DNA markers closely linked to the equine GBE1 gene would assist us in determining whether a mutation in this gene leads to the GSD IV-like...
Topics
- 1,4-alpha-Glucan Branching Enzyme
- Alleles
- Americas
- Animals
- Chromosome Mapping
- Genetic Linkage
- Glycogen Storage Disease Type IV
- Horse Diseases
- Horses
- In Situ Hybridization, Fluorescence
- Microsatellite Repeats
- Radiation Hybrid Mapping
- Sequence Analysis, DNA