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Article

The early onset dystonia protein torsinA interacts with kinesin light chain 1.

The Journal of biological chemistry - 7 May 2004

Kamm Christoph, Boston Heather, Hewett Jeffrey, Wilbur Jeremy, Corey David P, Hanson Phyllis I, Ramesh Vijaya, Breakefield Xandra O

Abstract excerpt

Early onset dystonia is a movement disorder caused by loss of a glutamic acid residue (Glu(302/303)) in the carboxyl-terminal portion of the AAA+ protein, torsinA. We identified the light chain subunit (KLC1) of kinesin-I as an interacting partner for torsinA, with binding occurring between the tetratricopeptide repeat domain of KLC1 and the carboxyl-terminal region of torsinA. Coimmunoprecipitation analysis...

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Source

Identifiers

PMID: 14970196
DOI: 10.1074/jbc.M401332200

Genes

KLC1
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The early onset dystonia protein torsinA interacts with kinesin light chain 1.PMID 14970196Read ↗

Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis.Semantic proximity Read ↗

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Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells.Semantic proximity Read ↗

The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein.Semantic proximity Read ↗

TorsinA and dystonia: from nuclear envelope to synapseSemantic proximity Read ↗

Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation.Semantic proximity Read ↗

Characterization of human torsinA and its dystonia-associated mutant form.Semantic proximity Read ↗

Biochemical and cellular analysis of human variants of the DYT1 dystonia protein, TorsinA/TOR1A.Semantic proximity Read ↗

The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.Semantic proximity Read ↗

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Transgenic mouse model of early-onset DYT1 dystoniaSemantic proximity Read ↗

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