Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alanine glyoxylate aminotransferase deficiency: biochemical and molecular genetic lessons from the study of a human disease.

Advances in enzyme regulation - 1 Jan 1992

Watts R W

Abstract excerpt

The decision to treat a patient with primary hyperoxaluria type 1 (PHI) by combined liver and kidney transplantation, the former to correct the metabolic lesion which was then thought to be deficiency of cytoplasmic 2-oxoglutarate:glyoxylate carboligase, and the latter to replace the organ which is destroyed, provided an opportunity to investigate the disease by modern biochemical methods. It was shown that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Biological Transport, Active
Share to Liver

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitochondria

Share to Molecular Sequence Data

Share to Mutation

Share to Protein Processing, Post-Translational

Share to Protein Sorting Signals

Source

Identifiers

PMID: 1496924
DOI: 10.1016/0065-2571(92)90024-t

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alanine glyoxylate aminotransferase deficiency: biochemical and molecular genetic lessons from the study of a human disease.PMID 1496924Read ↗

Molecular Aetiology of Primary Hyperoxaluria Type 1Semantic proximity Read ↗

Liver peroxisomal alanine:glyoxylate aminotransferase and the effects of mutations associated with Primary Hyperoxaluria Type I: An overview.Semantic proximity Read ↗

Molecular aetiology of primary hyperoxaluria and its implications for clinical management.Semantic proximity Read ↗

The molecular basis of alanine: glyoxylate aminotransferase mistargeting: the most common single cause of primary hyperoxaluria type 1.Semantic proximity Read ↗

Molecular insights into primary hyperoxaluria Type I pathogenesisSemantic proximity Read ↗

Primary hyperoxaluria type 1: genotypic and phenotypic heterogeneity.Semantic proximity Read ↗

Molecular etiology of primary hyperoxaluria type 1: new directions for treatment.Semantic proximity Read ↗

[Molecular pathology of type 1 primary hyperoxaluria].Semantic proximity Read ↗

A unique molecular basis for enzyme mistargeting in primary hyperoxaluria type 1.Semantic proximity Read ↗

Alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting in human hereditary kidney stone disease.Semantic proximity Read ↗

[From gene to disease; primary hyperoxaluria type I caused by mutations in the AGXT gene].Semantic proximity Read ↗

A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.