Article
Congenital thrombophilia among patients with venous thromboembolism.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Dec 1992
Melissari E, Monte G, Lindo V S, Pemberton K D, Wilson N V, Edmondson R, Das S, Kakkar V V
Abstract excerpt
During a 3-year period we studied 393 adult patients (382 of whom were unrelated) with a history of acute venous thromboembolism. A congenital deficiency state known to predispose to thrombosis was found in 27.2%. Of these, most were due to deficiencies of protein C (9.2%), protein S (7.6%), antithrombin III (5%) or to increased plasma PAI-1 concentration (3.1%) which, in the absence of any known factor that...
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