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Article

Large shifts in pathogen virulence relate to host population structure.

Science (New York, N.Y.) - 6 Feb 2004

Boots M, Hudson P J, Sasaki A

Abstract excerpt

Theory on the evolution of virulence generally predicts selection for an optimal level of virulence determined by trade-offs with transmission and/or recovery. Here we consider the evolution of pathogen virulence in hosts who acquire long-lived immunity and live in a spatially structured population. We show theoretically that large shifts in virulence may occur in pathogen populations as a result of a bistability...

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Identifiers

PMID: 14764881
DOI: 10.1126/science.1088542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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