Article
Genetics and biochemistry of primary congenital glaucoma.
Ophthalmology clinics of North America - 1 Dec 2003
Sarfarazi Mansoor, Stoilov Ivaylo, Schenkman John B
Abstract excerpt
Several observations noted by early investigators supported the supposition that in most cases, congenital glaucoma is determined by genetic factors. The genetic heterogeneity of PCG was confirmed by genetic linkage studies conducted in the 1990s when the authors determined that CYP1B1 is the congenital glaucoma gene at the GLC3A locus. The coding sequence of CYP1B1 has been subjected to extensive screening in...
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