Eye birth defects in humans may be caused by a recessively-inherited genetic predisposition to the effects of maternal vitamin A deficiency during pregnancy.

Article

Eye birth defects in humans may be caused by a recessively-inherited genetic predisposition to the effects of maternal vitamin A deficiency during pregnancy.

Medical science monitor : international medical journal of experimental and clinical research - 1 Nov 2003

Hornby Stella J, Ward Simon J, Gilbert Clare E

Abstract excerpt

Congenital malformations of the eye can cause blindness in children. They occur throughout the world and in most cases the aetiology is unknown. Linkage studies have largely been unsuccessful and the risk to siblings is generally low. Epidemiological and laboratory evidence support a hypothesis that there may be genetic (recessive) predisposition to the teratogenetic effects of mild to moderate maternal vitamin A...

Topics

Anophthalmos
Coloboma
Eye Abnormalities
Female
Genes, Recessive
Genetic Predisposition to Disease
Humans
Microphthalmos
Mutation
Pregnancy
Pregnancy Complications

Vitamin A Deficiency

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Eye birth defects in humans may be caused by a recessively-inherited genetic predisposition to the effects of maternal vitamin A deficiency during pregnancy.PMID 14586282Read

Congenital eye malformations: Clinical-epidemiological analysis of 1,124,654 consecutive births in SpainSemantic proximity Read

Congenital eye malformations: Clinical‐epidemiological analysis of 1,124,654 consecutive births in SpainSemantic proximity Read

Epidemiology of congenital eye malformations in 131,760 consecutive birthsSemantic proximity Read

Genetic and environmental factors contributing to anophthalmia and microphthalmia: Current understanding and future directionsSemantic proximity Read

Preimplantation genetic diagnosis as a strategy to prevent having a child born with an heritable eye disease.Semantic proximity Read

The genetic and molecular basis of congenital eye defects.Semantic proximity Read

Developmental eye disorders.Semantic proximity Read

[Genetic diseases of the eye].Semantic proximity Read